2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-119883
    A-61603 (free base） 750531-54-5 98%
    A-61603 free base is a potent adrenergic receptor agonist. A-61603 free base reduces carotid artery conductance in anesthetized pigs mediated by α1 and α2 adrenergic receptors (pEC50=7.25). A-61603 free base can be used as a probe to study adrenergic function.
    A-61603 (free base）
  • HY-119889
    A1B11 1602731-56-5 98%
    A1B11 is a selective SIRT inhibitor (SIRT2:IC50=5.3 μM) that can be used in the study of neurodegenerative diseases.
    A1B11
  • HY-119914
    Bromadol 77239-98-6 98%
    Bromadol is an opioid.
    Bromadol
  • HY-119946
    BF-1 518980-66-0 98%
    BF-1 is a 5-HT2B receptor antagonist with a pKi value of 10.05 and an IC50 value of 2.6 nM.
    BF-1
  • HY-119953
    BIBN-99 145301-48-0 98.02%
    BIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury.
    BIBN-99
  • HY-119997
    Disulergine 59032-40-5 98%
    Disulergine (CH 29-717) is an ergot alkaloid. Disulergine is a dopamine receptor agonist. Disulergine inhibits secretion of prolactin in rats. Disulergine inhibits growth hormone (GH) release.
    Disulergine
  • HY-120016
    RU 43044 136959-96-1 98%
    RU 43044 is an orally active, selective glucocorticoid receptor inhibitor. RU 43044 blocks glucocorticoid receptor activity and reverses the enhanced dopamine release induced by high potassium in the prefrontal cortex. RU 43044 also inhibits thymocyte receptor down-regulation induced by high-dose glucocorticoids without affecting thymocyte apoptosis or basal receptor expression. RU 43044 is widely applicable to research related to depression.
    RU 43044
  • HY-120045
    DuP 747 142515-44-4 98%
    DuP 747 is a select opioid kappa agonist analgesic amine.
    DuP 747
  • HY-120092
    BMT-046091 1551401-20-7 98%
    BMT-046091 is a selective inhibitor of adaptor-associated kinase 1 (AAK1). BMT-046091 inhibits phosphorylation of the μ2 peptide by AAK1 with an IC50 value of 2.8 nM.
    BMT-046091
  • HY-12012R
    SB 216763 (Standard) 280744-09-4 98%
    SB 216763 (Standard) is the analytical standard of SB 216763. This product is intended for research and analytical applications. SB 216763 is potent, selective and ATP-competitive GSK-3 inhibitor with IC50s of 34.3 nM for both GSK-3α and GSK-3β.
    SB 216763 (Standard)
  • HY-120192
    CGP 62349 187608-26-0 98%
    CGP 62349 is a selective and orally active GABAB receptor antagonist that improves cognitive performance in multiple learning paradigms.
    CGP 62349
  • HY-120206
    Brasofensine 171655-91-7 98%
    Brasofensine (BMS-204756) is an oral active dopamine transporter antagonist and can be used for parkinson’s disease research.
    Brasofensine
  • HY-120276
    Golexanolone 2089238-18-4 98%
    Golexanolone is a GABAA receptor modulating steroid antagonist. Golexanolone reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in hyperammonemic rats.
    Golexanolone
  • HY-120308
    (R)-Nolpitantium 154728-59-3 98%
    (R)-Nolpitantium is the R-enantiomer of Nolpitantium (HY-108479). Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation.
    (R)-Nolpitantium
  • HY-120410
    DL-4662 1674389-55-9 98%
    DL-4662 is a 3,4-dimethoxy derivative that can be identified using techniques such as, GC-EI-MS, LC-tandem mass spectrometry and NMR spectroscopy.
    DL-4662
  • HY-120426
    MMDPPO 146322-08-9 98%
    MMDPPO is an Amphetamine compound.
    MMDPPO
  • HY-120464
    PF-05212377 1226793-34-5 98%
    PF-05212377 (SAM-760) is an inhibitor for serotonin receptor 5-HT6. PF-05212377 is a substrate for P-gp/non-BCRP human transporter. PF-05212377 exhibits blood brain barrier permeability in non-human primates. PF-05212377 can be used for Alzheimer’s Disease research.
    PF-05212377
  • HY-120476
    JNJ-39729209 1160606-90-5 98%
    JNJ-39729209 is an antagonist for transient receptor potential vanilloid 1 (TRPV1) with pIC50 of 7.9, 8.5, 7.9 and 7.7 for TRPV1 from human, rat, canine and guinea pig. JNJ-39729209 inhibits Capsaicin (HY-10448)-induced hypotension and inhibit thereby hypothermia. JNJ-39729209 exhibits anti-inflammatory and analgesic activities in Carrageenan (HY-125474)- and CFA (HY-153808)-induced thermal hyperalgesia rat models. JNJ-39729209 exhibits anti-cough effects in guinea pigs.
    JNJ-39729209
  • HY-120479
    Cythioate 115-93-5 98%
    Cythioate is an organophosphorous insecticide and anthelmintic. Cythioate is an acetylcholinesterase inhibitor which interferes with neuromuscular transmission in ectoparastites.
    Cythioate
  • HY-120481
    JNJ-40413269 1184847-16-2 98%
    JNJ-40413269 is an inhibitor for FAAH, that inhibits human FAAH and rats FAAH with IC50 of 28 nM and 270 nM. JNJ-40413269 exhibits analgesic efficacy in rat spinal nerve ligation model and exhibits good pharmacokinetic characteristics in rats.
    JNJ-40413269
Cat. No. Product Name / Synonyms Application Reactivity